Not all cancer mutations are equal: Mutation strength in a single gene shapes tumor behavior

Cancer is often thought of as a single disease. Yet even tumors that arise in the same organ can follow very different genetic paths. A new study shows that these differences can sometimes be traced back to tiny changes in a single gene. Research led by senior researcher Dr. Derya Deniz Özdemir from Koç University School of Medicine and the Research Center for Translational Medicine (KUTTAM), published in Nature Genetics, reveals that mutations in one of the most frequently altered genes in cancer do not all have the same effect.