Large imaging study changes understanding of the origins of Parkinson's rest tremor

A Finnish clinical imaging study shows that rest tremor in Parkinson's disease is not explained by greater dopamine loss. In contrast, tremor appears to be associated with relatively better-preserved dopamine function. Researchers from the University of Turku and Turku University Hospital, Finland, analyzed clinical data and dopamine transporter (DAT) imaging data from 414 Finnish patients. The cohort consisted of patients examined in routine clinical practice for uncertain parkinsonism or tremor, making the findings exceptionally well generalizable to real-world clinical settings. The results are published in Neurology.